By Alex Avdeef
Explains tips on how to practice and study the result of the most recent physicochemical methods
With this e-book as their advisor, readers have entry to the entire present details had to completely examine and effectively ensure a compound's pharmaceutical houses and their results on drug absorption. The ebook emphasizes oral absorption, explaining the entire physicochemical tools used this present day to investigate drug applicants. in addition, the writer offers specialist advice to aid readers research the result of their reports to be able to opt for the main promising drug candidates.
This Second Edition has been completely up to date and revised, incorporating all of the most modern study findings, equipment, and assets, including:
Descriptions and functions of recent PAMPA versions, drawing on greater than thirty papers released by means of the author's learn group
Two new chapters interpreting permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded details and strategies to help pKa determination
New examples explaining the remedy of essentially insoluble try compounds
Additional case stories demonstrating using the most recent physicochemical techniques
New, revised, and increased database tables in the course of the book
Well over 2 hundred drawings aid readers greater comprehend tough options and supply a visible consultant to advanced methods. additionally, over 800 references function a gateway to the first literature within the box, facilitating additional study into all of the themes coated within the book.
This Second Edition is suggested as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different comparable parts of study. it's also prompt as a supplemental textual content for graduate classes in pharmaceutics.
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Extra resources for Absorption and Drug Development: Solubility, Permeability, and Charge State
Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef